Couple of my favorite places/things to do in Reno:
1. Buffalo Progressive at Atlantis
2. Mel's Diner at the Sands (best to visit during daylight hours)
3. Jerry's Nugget (Sparks) -- good peoplewatching
4. Peppermill Slot Chairs -- like butter
5. Lake Tahoe is 1 hr away, but don't do the drive during rush hour or on a Friday or weekend day.